Foundation Medicine's Comprehensive Genomic Profile Informs Therapeutic Choices and Leads to Promising Outcomes in Pediatric Patients With Gliomas
New Clinical Data Presented at the 3rd
Pediatric glioma is a group of brain tumors that start in the glial
cells of children. According to the
"The toxicity and side effects associated with the standard of care
represent significant challenges in treating brain cancers in children,"
Tumor samples from 75 pediatric patients underwent comprehensive genomic profiling in the course of clinical care using the FoundationOne assay, revealing that 89% of cases harbored at least one clinically relevant genomic alteration. Pediatric gliomas frequently harbored clinically relevant genomic alterations in BRAF (29%), CDKN2A/B (15%), NF1 (14%), PIK3CA (14%) and EGFR (11%). Ten cases (14%) harbored a BRAF fusion, including 44% (4 of 9) of the pilocytic astrocytoma cases. Treatment for these patients commonly includes radiation therapy (XRT) or chemotherapy, with the choice of modality depending on the assessment of tumor prognosis. Previous studies show that presence of BRAF fusions correlates with disease carrying a better prognosis, as well as being exquisitely sensitive to chemotherapy. Based on the identification of these BRAF fusions, four patients were treated with chemotherapy resulting in partial to complete responses for these patients, while avoiding possible sequelae from treatment with XRT. These findings validate comprehensive genomic profiling as a key component of clinical care capable of detecting all classes of gene alterations across pediatric gliomas and providing key diagnostic insights to inform treatment decisions. A large majority of pediatric gliomas harbor at least one clinically relevant cancer gene alteration, and the detection of these can lead to better treatment decisions and outcomes.
"There are few things as devastating to childhood as brain cancer," said
Cautionary Note Regarding Forward-Looking Statements
This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995, including, but not limited to, statements regarding the ability of FoundationOne to identify clinically relevant genomic alterations, the benefits to patients of comprehensive genomic profiling of their tumors, the utility of FoundationOne in informing treatment of certain patient populations, the ability of FoundationOne to affect the prognosis, treatment or diagnosis of cancer patients, and clinical data related to FoundationOne. All such forward-looking statements are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in or implied by such forward-looking statements. These risks and uncertainties include the risks that Foundation Medicine's products will not be able to identify genomic alterations in the same manner as prior clinical data; and the risks described under the caption "Risk Factors" in Foundation Medicine's Annual Report on Form 10-K for the year ended December 31, 2014, which is on file with the Securities and Exchange Commission, as well as other risks detailed in Foundation Medicine's subsequent filings with the Securities and Exchange Commission. All information in this press release is as of the date of the release, and Foundation Medicine undertakes no duty to update this information unless required by law.
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